Updated 6/11/2026, reading time approx. 5 minutes
Is microdosing with psychedelics safe?
Is microdosing safe?
Yes, microdosing with psychedelics is safe for most people. Extensive research has been conducted on the health risks associated with the use of psilocybin (magic mushrooms, truffles), LSD, and other psychedelics. Virtually all studies indicate that there is little to no risk to mental or physical health, and the risk of addiction with these substances is negligible.
With microdosing you only take very small amounts, so you can assume that any risks are even lower. Provided you stick to the prescriptions and dosage, you should not expect any problems. If you take more than the prescribed dose, the risk increases slightly. How much more the risk increases depends entirely on how much you consume and with which psychedelic. But even with large quantities, the risk is still low.
To put the risks and harmfulness of magic mushrooms, truffles, and LSD into perspective, the chart below compares these substances with everyday items such as alcohol and tobacco. The chart shows, on a scale of 0 to 100, the risk each substance poses to the user’s health and the risk of harm to those around them.
Alcohol is 10 to 12 times more harmful than magic mushrooms, truffles, and LSD!
(source: Drug Harm Index).
Microdosing in mental health problems and pregnancy
On a side note, people with mental disorders and a predisposition to epilepsy, schizophrenia or psychosis, for example, should be extra cautious when using psychedelics (including microdosing). Furthermore, the use of psychedelics is not recommended in combination with some medications, during pregnancy and when breastfeeding.
If this applies to you but you’re still considering microdosing, consult your doctor or another healthcare professional first.
Possible side effects
A 2019 study involving 5,000 participants, led by the renowned psychologist and researcher Dr. James Fadiman, found that approximately 4% of people who microdose experience side effects or adverse effects (source: Might Microdosing Be Safe and Beneficial? An Initial Exploration).
The most commonly mentioned side effects are:
- Fatigue (often this is disconnected fatigue)
- Dealing with changes in awareness and sensitivity can be challenging
- Mild nausea or stomach upset (with magic mushrooms and truffles)
- Slight headache (with shrooms and truffles)
- Tinnitus (tinnitus) can get temporarily worse
- People with color blindness sometimes report seeing mild hallucinations and rays or "afterimages"
People diagnosed with bipolar disorder, report that they do benefit from microdosing during a depressive phase, but would advise against it during a manic phase.
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Feel better with microdosing
Are you ready? Then start microdosing now.
Our 1P-LSD Microdosing Kits consist of a spray bottle (10ml) containing 200mcg or 400mcg of 1P-LSD, instructions and a storage pouch in which you can store the spray bottle sealed. The bottle contains 200 sprays with 1mcg (normal) or 2mcg (strong) 1P-LSD per spray.
One bottle allows you to microdose for 2 to 3 months.
Interaction with other agents
Combining psychedelics with other drugs or medications can be dangerous. If you are on medication and are considering microdosing, always consult a doctor or other professional first, and/or do your own research.
Combination with amphetamines
Amphetamines (such as "speed") are stimulants. When combined with psychedelics, they can be quite dangerous. People may start acting strangely and may injure themselves or others in the process.
Combination with cannabis
The combination of psychedelics with cannabis is considered very pleasant by experienced cannabis users. If you are not so experienced with cannabis, this combination is not recommended - or be extremely careful with it. It can cause confusion and uncontrolled behavior.
Combination with cocaine
Cocaine is a powerful stimulant. When combined with psychedelics, it can cause hallucinations, paranoia and delusions. The dangers are similar to those of amphetamines.
Combination with alcohol
Alcohol tends to weaken the effects of psychedelics.
Combination with antidepressants
Mixing lithium and/or tricyclic antidepressants with psychedelics can be lethal in rare cases.
Combination with anti-epileptic drugs
Combining psychedelics with antiepileptic drugs is unwise. Anti-epileptics have a dampening effect, so combining them with psychedelics can have unpredictable and dangerous consequences. Furthermore, psychedelics can trigger seizures in people who are prone to them.
Combination with antihypertensive medications
No research has been done on interactions between psychedelics and antihypertensive drugs. The combination is rejected because of the expected adverse effects.
Combination with antipsychotics
If you suffer from psychosis, it is a bad idea to use psychedelics (including microdosing).
Combination with pain medication
The risks of combining psychedelics and pain medication depend on the type of medication. For paracetamol and ibuprofen, there are no known interactions. This does not mean there are no risks. For heavier pain medications such as oxycodone or tramadol, the risks may be greater. For these, the combination is known to potentially increase the risk of stroke
Never microdose in combination with Tramadol or Lithium!
Microdosing, or not microdosing?
If you are healthy and in good physical condition and are not taking any medications, you can start microdosing. If you are taking medications, consult a doctor if possible to make sure that the medications you are taking do not interact with the substance you want to microdose (there is a lot of information available online about this topic).
If you have mental health issues, if you suffer from psychosis or a mental disorder, if you have epilepsy or if you are under treatment, be extra careful when microdosing psychedelics and consult a doctor, therapist or other professional before you start microdosing.
The user himself is responsible for any adverse effects of microdosing.
More on the risks of microdosing
Risks and Side Effects of Microdosing (Microdosing Institute)
Experience: Negative effects during microdosing (Microdosing Institute)
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Frequently Asked Questions
Are psychedelics harmful to health? What are the risks?
Microdosing with psychedelics is safe for most people.
Much research has been done on the health risks associated with the use of psilocybin (paddos, truffles), LSD and other psychedelics. Almost all studies have found little to no risk to mental or physical health and zero risk of addiction with these substances.
With microdosing you only take very small amounts, so you can assume that any risks are even lower. Provided you stick to the prescriptions and dosage you should not expect any problems.
If you take more than the prescribed dose, the risk increases slightly. How much more the risk increases depends entirely on how much you consume and with which psychedelic. But even with large quantities, the risk is still low.
Also read:
Is microdosing safe?I am healthy/fit. Can I just start microdosing then?
If you are healthy and fit and not on any medication, you can start microdosing with confidence.
If you are on medication, consult a doctor if possible to make sure the medications you are taking do not interact with the drug you want to microdose with (there is a lot of information online on this topic).
If you have mental health issues, if you suffer from psychosis or a mental disorder, if you have epilepsy, or if you are currently undergoing treatment, please exercise extra caution when microdosing psychedelics. Always consult a doctor, therapist, or other professional (*) before you start microdosing (if you decide to do so).
Also read:
Microdosing, or not microdosing?I suffer from psychosis, schizophrenia or other psychological symptoms. Can I microdose?
People with mental disorders and a predisposition to schizophrenia or psychosis, for example, should be extra careful when using psychedelics (even when microdosing!).
Do you still want to microdose? Contact your doctor, therapist or other professional before you start. The use of psychedelics with the aforementioned symptoms can have serious (mental) consequences.
Also read:
Microdosing guide
Microdosing for psychological symptomsI have epilepsy. Can I microdose safely?
Psychedelics have been known to trigger seizures (however, this is rare).
Do you still want to microdose? Then check with your doctor or other professional before you start. Using psychedelics with epilepsy can have serious consequences.
Also read:
Microdosing guideI have Tinnitus. Is this a risk with microdosing?
Tinnitus (tinnitus) may temporarily get worse. Once the drug wears off, the side effect also disappears.
Can I use painkillers/pain medication if I microdose?
The risks of combining psychedelics and pain medication depend on the type of medication. For paracetamol and ibuprofen, there are no known interactions. This does not mean that there are no risks.
For heavier pain medications such as oxycodone or tramadol, the risks may be greater. Of these, the combination is known to potentially increase the risk of stroke.
Also read:
Interaction with other agentsCan I microdose in combination with other drugs or medications?
Combining psychedelics with other drugs or medications can be dangerous. If you are on medication and are considering microdosing, always consult a doctor or other professional first, and/or do your own research.
Combinations and the reactions they can cause include:
Combination with amphetamines
Amphetamines (such as "speed") are stimulants. When combined with psychedelics, they can be quite dangerous. People may start acting strangely and may injure themselves or others in the process.Combination with cannabis
The combination of psychedelics with cannabis is considered very pleasant by experienced cannabis users. If you are not so experienced with cannabis, this combination is not recommended - or be extremely careful with it. It can cause confusion and uncontrolled behavior.Combination with cocaine
Cocaine is a powerful stimulant. When combined with psychedelics, it can cause hallucinations, paranoia and delusions. The dangers are similar to those of amphetamines.Combination with alcohol
Alcohol tends to weaken the effects of psychedelics.Combination with antidepressants
Mixing lithium and/or tricyclic antidepressants with psychedelics can be fatal in rare cases.Combining with anti-epileptics
Combining psychedelics with anti-epileptics is unwise. Anti-epileptics have a dampening effect, so combining them with psychedelics can have unpredictable and dangerous consequences. Furthermore, psychedelics can trigger seizures in people who are prone to them.Combination with antihypertensive drugs
No research has been done on interactions between psychedelics and antihypertensive drugs. The combination is rejected because of the expected adverse effects.Combination with antipsychotics
If you suffer from psychosis, it is a bad idea to use psychedelics (including microdosing).Combination with pain medication
The risks of combining psychedelics and pain medication depend on the type of medication. For paracetamol and ibuprofen, there are no known interactions. This does not mean there are no risks. For heavier pain medications such as oxycodone or tramadol, the risks may be greater. For these, the combination is known to potentially increase the risk of stroke.Never microdose in combination with Tramadol or Lithium!
Also read:
Interaction with other agents