What is "microdosing"?
Microdosing involves taking a minimal dose of a psychoactive substance periodically (for example, twice a week). In microdosing, you experience all the positive and healing effects of the drug. But, because you take a very small dose, you do not "trip" or hallucinate. This makes it extremely suitable for use in everyday life.
Microdosing is done for a variety of reasons. The most frequently mentioned are: more energy, better concentration, more creativity, better sleep, reduction of depression, stress, burnout and easier work or study.
What does microdosing do to your brain?
Psychedelics reduce activity in a very important brain network, the default mode network. This network is involved in everything related to our sense of self, thought processes and self-reflection; it is where the "ego" resides and where you derive your identity and self-image. In people suffering from depression, anxiety disorder, stress, burnout, adhd/add or addiction, the default mode network is often disturbed and overactive.
Because psychedelics reduce the activity of the default mode network, microdosing gives you more peace within yourself. Worrying, excessive thinking and deep-rooted thought patterns fade away, it becomes quieter in your thought world. You get more space in your head, suddenly start seeing things more clearly, you become more aware of yourself and it becomes easier to manifest changes in your life, such as smoking less, living healthier, taking up a study or finishing a project.
Psychedelics also decrease blood flow to the hypothalamus, This is the brain area that regulates hormone levels and influences mood and stress. As a result, "things affect you less. You are less likely to become unbalanced, less likely to be irritable and more positive in responding to situations where you normally experience tension or negativity.
Microdosing for depression, stress and burnout
Microdosing has received increasing attention in recent years as a potential treatment for depression and burnout. Although much research is still needed, there is promising evidence that microdosing can help improve mood, energy and overall well-being in people dealing with mental health problems such as depression or burnout.
The benefits of microdosing
- Improved mood: Many microdosers experience improved mood/better mood and a heightened sense of well-being. Small amounts of psychedelics can affect the brain in a way that stimulates the production of neurotransmitters such as serotonin and dopamine, which can lead to improved mood and greater resilience against depressive feelings. Source: Psychedelic Science Review - Microdosing Psychedelics: An Emerging Treatment for Depression
- Increased energy and motivation: Microdosing can also lead to an increase in energy and motivation, which is essential for people suffering from burnout. The subtle effects of microdosing can help reduce fatigue and increase enthusiasm and motivation for daily activities.
- Improved focus and concentration: People with depression and burnout can often have difficulty focusing on tasks and completing tasks. Microdosing can help improve focus and concentration, making it easier to be productive and complete tasks effectively.
- Less (compulsive) thinking and brooding: Microdosing decreases compulsive thinking, brooding and negative thinking patterns in most people.
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Microdosing versus antidepressants
While traditional antidepressants are often the first line of treatment for depression and burnout, there are some important differences between these medications and microdosing with psychedelics.
Below is a comparison of the benefits of microdosing versus antidepressants.
1. Natural approach: Antidepressants are often synthetic drugs that affect chemical processes in the brain. Microdosing, on the other hand, uses natural psychedelics such as LSD(yes, even LSD is basically a natural drug, namely ergot), psilocybin and ayahuasca, which come from plants or fungi. For many people, natural treatment is more appealing than swallowing synthetic drugs.
2. Fewer side effects: Many traditional antidepressants have side effects such as drowsiness, weight gain, sexual dysfunction and emotional flattening. Microdosing does not have these side effects. This can be an advantage for people who are sensitive to the side effects of antidepressants.
3. Potentially long-term effects: Although antidepressants often provide immediate relief of symptoms, they are often less effective in the long term and the positive effect may level off over time. Microdosing has long-term effects in most people, even after use is stopped. Some people report lasting improvements in mood, energy and overall well-being after microdosing.
4. Mind-Body connection: Microdosing with psychedelics can promote a deeper connection with the body and mind, which can contribute to your healing and well-being. This aspect of microdosing has been seen as one of the most valuable additions to traditional treatments: it puts more emphasis on healing the underlying causes of depression and burnout, where traditional medications often do symptom relief.
5. Individual adjustment: An advantage of microdosing is that you can adjust dosage and frequency at any time to suit your individual needs and preferences. This can result in a more personalized and flexible approach to treatment, giving the user more control over his or her well-being.
Are you dealing with depression or burnout yourself and considering microdosing?
Then read the comprehensive microdosing guide before you get started.
Experiences of others
People's experiences with microdosing for depression and burnout.
- Annelies, 34: Annelies had been suffering from depression for years and found that traditional treatments were not effective enough. After discovering microdosing with psilocybin truffles, she saw a significant improvement in her mood and overall well-being. She felt more energetic, more motivated and could finally enjoy the little things in life.
- Jasper, 40: Jasper experienced severe burnout after years of overwork and stress. Traditional therapies did not help him much, but after starting to microdose LSD, he noticed a significant improvement in his energy levels and resilience. He was able to slowly but surely rebuild his life and regain control of his well-being. Source: The Guardian - My Psychedelic Cure for Depression
- Eva, 29: Eva suffered from severe depression and had difficulty performing her daily tasks. After microdosing ayahuasca, she noticed a gradual relief of her symptoms and a greater sense of inner peace. She was able to find herself again and rediscover her life with a renewed sense of hope. Source: MAPS - The Therapeutic Potential of Ayahuasca
- Max, 38: Max felt exhausted and emotionally drained due to his burnout. Microdosing mescaline gave him a new perspective on life and helped him appreciate the positive aspects of his environment. He was able to balance himself better and find a healthier relationship with work and rest.
- Sophie, 26: Sophie struggled with severe depression and often felt overwhelmed by negative thoughts and feelings of hopelessness. After microdosing ibogaine, she noticed a radical shift in her perspective and was able to free herself from the grip of her depression. She felt alive again and hopeful for the future. Source: Psychology Today - A Personal Account of Microdosing Iboga
While the benefits of microdosing for depression and burnout are promising, it is important to note that this practice is not suitable for everyone. Always consult a qualified health care provider before beginning microdosing, especially if you are already on medication or have other medical conditions. While research on microdosing continues, these personal stories offer a glimpse of the hope and healing this practice can offer for those suffering from depression and burnout.
See also
Freke does microdosing: 'Makes me a better mom and finer friend'
Experiences with microdosing
Conclusion
It is important to note that microdosing is not for everyone and the effect is different for each person. Some people may not experience relief from depression or burnout, while others may benefit greatly. It is also important to know that microdosing is not a replacement for professional therapy or medical treatment, but rather a complementary approach.
If you are considering starting microdosing for depression or burnout, is first do research on the possible risks and benefits. Talk to your primary care physician therapist or other qualified health care provider before starting.

Microdosing against depression and burnout, microdosing versus antidepressants.
This article is based on experiences of people microdosing with LSD, truffles and magic mushrooms.
See also our disclaimer.